Skeletal muscle loss: cachexia, sarcopenia, and inactivity
نویسندگان
چکیده
منابع مشابه
Skeletal muscle loss: cachexia, sarcopenia, and inactivity.
Loss of skeletal muscle mass occurs during aging (sarcopenia), disease (cachexia), or inactivity (atrophy). This article contrasts and compares the metabolic causes of loss of muscle resulting from these conditions. An understanding of the underlying causes of muscle loss is critical for the development of strategies and therapies to preserve muscle mass and function. Loss of skeletal muscle pr...
متن کاملResearch on cachexia, sarcopenia and skeletal muscle in cardiology
BACKGROUND The awareness of cardiac cachexia, i.e. involuntary weight loss in patients with underlying cardiovascular disease, has increased over the last two decades. METHODS AND RESULTS This mini-review looks at recent research in the cardiovascular literature that is relevant to the areas of interest of the Journal of Cachexia, Sarcopenia and Muscle. It identifies significant research in t...
متن کاملSkeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training
Skeletal muscle provides a fundamental basis for human function, enabling locomotion and respiration. Transmission of external stimuli to intracellular effector proteins via signalling pathways is a highly regulated and controlled process that determines muscle mass by balancing protein synthesis and protein degradation. An impaired balance between protein synthesis and breakdown leads to the d...
متن کاملConference on ‘Nutrition and age-related muscle loss, sarcopenia and cachexia’ Symposium 2: Mechanisms for loss of muscle mass, strength and clinical measurement of malnutrition and cachexia The wasting continuum in heart failure: from sarcopenia to cachexia
Sarcopenia (muscle wasting) and cachexia share some pathophysiological aspects. Sarcopenia affects approximately 20 %, cachexia <10 % of ambulatory patients with heart failure (HF). Whilst sarcopenia means loss of skeletal muscle mass and strength that predominantly affects postural rather than non-postural muscles, cachexia means loss of muscle and fat tissue that leads to weight loss. The was...
متن کاملLoss of muscle mass: current developments in cachexia and sarcopenia focused on biomarkers and treatment
Loss of muscle mass arises from an imbalance of protein synthesis and protein degradation. Potential triggers of muscle wasting and function are immobilization, loss of appetite, dystrophies and chronic diseases as well as aging. All these conditions lead to increased morbidity and mortality in patients, which makes it a timely matter to find new biomarkers to get a fast clinical diagnosis and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2010
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.2010.28608a